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Stem cell-based therapy for targeting skin-to-brain cancer

"Metastatic brain tumors -- often from lung, breast or skin cancers -- are the most commonly observed tumors within the brain and account for about 40 percent of advanced melanoma metastases. Current therapeutic options for such patients are limited, particularly when there are many metastases," says Khalid Shah, MS, PhD, director of the Center for Stem Cell Therapeutics and Imaging (CSTI) in the BWH Department of Neurosurgery, who led the study. "Our results are the first to provide insight into ways of targeting multiple brain metastatic deposits with stem-cell-loaded oncolytic viruses that specifically kill dividing tumor cells." In their search for novel, tumor-specific therapies that could target multiple brain metastases without damaging adjacent tissues, the research team first developed different BRAF wild type and mutant mouse models that more closely mimic what is seen in patients. They found that injecting patient-derived, brain-seeking melanoma cells...

Neural stem cells steered by electric fields in rat brain

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Transplants of neural stem cells may be used to deal with mind accidents, however the best way to get them to the appropriate location? UC Davis researcher Min Zhao and Junfeng Feng, a neurosurgeon at Ren Ji Hospital, Shanghai, confirmed that they will steer transplanted stem cells (inexperienced, in inset on proper) to 1 a part of a rat's mind utilizing electrical fields. Credit score: Junfeng Feng Electrical fields can be utilized to information neural stem cells transplanted into the mind in the direction of a selected location. The analysis, revealed July 11 within the journal  Stem Cell Reviews , opens potentialities for successfully guiding stem cells to restore mind injury. Professor Min Zhao on the College of California, Davis Faculty of Medication's Institute for Regenerative Cures research how electrical fields can information wound therapeutic. Broken tissues generate weak electrical fields, and Zhao's analysis has proven how these elect...

Hormone replacement therapies help breast cancer grow, spread

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Hormone alternative therapies, or drugs containing feminine hormones, might assist most cancers to unfold. Credit score: © Ivelin Radkov / Fotolia Hormone alternative therapies, or drugs containing feminine hormones that substitute these now not produced by the physique, usually are prescribed to cut back the results of menopausal signs in ladies. Analysis has indicated that ladies who take hormone alternative therapies have a better incidence of breast most cancers. Now, researchers on the College of Missouri have linked pure and artificial progestins to the physique's manufacturing of specialised most cancers cells that act like stem cells in people. Findings may assist scientists goal these uncommon cells that proliferate in breast cancers and metastasize elsewhere, and should assist clinicians determine immunotherapies to fight the unfold of the illness. "In earlier research, we now have proven that each pure and artificial progestins speed up the ev...