First 'haploid' human stem cells could change the face of medical research
Haploid human embryonic stem cells.
Credit score: Azrieli Heart for Stem Cells and Genetic Analysis at Hebrew College
Stem cell analysis holds big potential for drugs and human well being. Specifically, human embryonic stem cells (ESCs), with their potential to show into any cell within the human physique, are important to the longer term prevention and therapy of illness.
One set or two? Diploid versus haploid cells
A lot of the cells in our physique are diploid, which suggests they carry two units of chromosomes -- one from every father or mother. Till now, scientists have solely succeeded in creating haploid embryonic stem cells -- which include a single set of chromosomes -- in non-human mammals akin to mice, rats and monkeys. Nonetheless, scientists have lengthy sought to isolate and replicate these haploid ESCs in people, which might permit them to work with one set of human chromosomes versus a combination from each dad and mom.
This milestone was lastly reached when Ido Sagi, working as a PhD scholar on the Hebrew College of Jerusalem's Azrieli Heart for Stem Cells and Genetic Analysis, led analysis that yielded the primary profitable isolation and upkeep of haploid embryonic stem cells in people. In contrast to in mice, these haploid stem cells had been capable of differentiate into many different cell sorts, akin to mind, coronary heart and pancreas, whereas retaining a single set of chromosomes.
With Prof. Nissim Benvenisty, Director of the Azrieli Heart, Sagi confirmed that this new human stem cell sort will play an vital position in human genetic and medical analysis. It'll support our understanding of human growth -- for instance, why we reproduce sexually as an alternative of from a single father or mother. It'll make genetic screening simpler and extra exact, by permitting the examination of single units of chromosomes. And it's already enabling the research of resistance to chemotherapy medicine, with implications for most cancers remedy.
Diagnostic kits for personalised drugs
Primarily based on this analysis, Yissum, the Expertise Switch arm of the Hebrew College, launched the corporate New Stem, which is growing a diagnostic equipment for predicting resistance to chemotherapy therapies. By amassing a broad library of human pluripotent stem cells with completely different mutations and genetic makeups, NewStem plans to develop diagnostic kits for personalised medicine and future therapeutic and reproductive merchandise.
2017 Kaye innovation Award
In recognition of his work, Ido Sagi was awarded the Kaye Innovation Award for 2017.
The Kaye Innovation Awards on the Hebrew College of Jerusalem have been awarded yearly since 1994. Isaac Kaye of England, a outstanding industrialist within the pharmaceutical trade, established the awards to encourage college, employees and college students of the Hebrew College to develop modern strategies and innovations with good business potential, which can profit the college and society.
Ido Sagi acquired BSc summa cum laude in Life Sciences from the Hebrew College, and at present pursues a PhD on the laboratory of Prof. Nissim Benvenisty on the college's Division of Genetics within the Alexander Silberman Institute of Life Sciences. He's a fellow of the Adams Fellowship of the Israel Academy of Sciences and Humanities, and has just lately acquired the Rappaport Prize for Excellence in Biomedical Analysis. Sagi's analysis focuses on finding out genetic and epigenetic phenomena in human pluripotent stem cells, and his work has been printed in main scientific journals, together with Nature, Nature Geneticsand Cell Stem Cell.
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A lot of the cells in our physique are diploid, which suggests they carry two units of chromosomes -- one from every father or mother. Till now, scientists have solely succeeded in creating haploid embryonic stem cells -- which include a single set of chromosomes -- in non-human mammals akin to mice, rats and monkeys. Nonetheless, scientists have lengthy sought to isolate and replicate these haploid ESCs in people, which might permit them to work with one set of human chromosomes versus a combination from each dad and mom.
This milestone was lastly reached when Ido Sagi, working as a PhD scholar on the Hebrew College of Jerusalem's Azrieli Heart for Stem Cells and Genetic Analysis, led analysis that yielded the primary profitable isolation and upkeep of haploid embryonic stem cells in people. In contrast to in mice, these haploid stem cells had been capable of differentiate into many different cell sorts, akin to mind, coronary heart and pancreas, whereas retaining a single set of chromosomes.
With Prof. Nissim Benvenisty, Director of the Azrieli Heart, Sagi confirmed that this new human stem cell sort will play an vital position in human genetic and medical analysis. It'll support our understanding of human growth -- for instance, why we reproduce sexually as an alternative of from a single father or mother. It'll make genetic screening simpler and extra exact, by permitting the examination of single units of chromosomes. And it's already enabling the research of resistance to chemotherapy medicine, with implications for most cancers remedy.
Diagnostic kits for personalised drugs
Primarily based on this analysis, Yissum, the Expertise Switch arm of the Hebrew College, launched the corporate New Stem, which is growing a diagnostic equipment for predicting resistance to chemotherapy therapies. By amassing a broad library of human pluripotent stem cells with completely different mutations and genetic makeups, NewStem plans to develop diagnostic kits for personalised medicine and future therapeutic and reproductive merchandise.
2017 Kaye innovation Award
In recognition of his work, Ido Sagi was awarded the Kaye Innovation Award for 2017.
The Kaye Innovation Awards on the Hebrew College of Jerusalem have been awarded yearly since 1994. Isaac Kaye of England, a outstanding industrialist within the pharmaceutical trade, established the awards to encourage college, employees and college students of the Hebrew College to develop modern strategies and innovations with good business potential, which can profit the college and society.
Ido Sagi acquired BSc summa cum laude in Life Sciences from the Hebrew College, and at present pursues a PhD on the laboratory of Prof. Nissim Benvenisty on the college's Division of Genetics within the Alexander Silberman Institute of Life Sciences. He's a fellow of the Adams Fellowship of the Israel Academy of Sciences and Humanities, and has just lately acquired the Rappaport Prize for Excellence in Biomedical Analysis. Sagi's analysis focuses on finding out genetic and epigenetic phenomena in human pluripotent stem cells, and his work has been printed in main scientific journals, together with Nature, Nature Geneticsand Cell Stem Cell.
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